Rheumatism is not a hereditary disease in the full sense of the word, but it has a certain tendency to be inherited. In addition, there is also a relationship with external factors such as environment and living habits. Since rheumatism is a large group of diseases, including more types, it can be divided into three categories according to the strength of the genetic relationship.1. Closer relationship with genetics: for example, ankylosing spondylitis, its development and genetic factors are relatively close. The rate of human leukocyte antigen (HLA) B27 positivity among patients is very high, accounting for more than 90% of patients. In the general population, the carriage rate of this gene is relatively low, and HLA-B27-positive people have a 20-40 times higher chance of developing ankylosing spondylitis than the normal population; 2, and genetic relationship: such as systemic lupus erythematosus, rheumatoid arthritis, scleroderma, etc., the cause and pathogenesis is not very clear, but through more basic research found that genetic factors in rheumatoid However, through more basic research, it is found that genetic factors play a relatively important role in the attack of rheumatoid rheumatism, systemic lupus erythematosus and other diseases; 3.