A patient with regular follow-up after gastric cancer surgery found that tumor markers CA153, CA199 and CA242 were progressively elevated in retesting, so he was very nervous, had trouble eating and losing weight, and decided in his heart that it was a recurrence, and his mood was very low. He had consulted some hospitals, but the stories were different. He was anxious about whether to continue chemotherapy and wait for observation, and then he was introduced to me by a friend, and there were similar cases in my patient group. After carefully understanding his condition, I advised him to test his gastric function and do C14 breath test to determine whether he had H. pylori infection, and the result was positive. After more than a month of anti-Helicobacter pylori treatment, the tumor marker was gradually reduced to normal, and he was so happy that he regained his vitality and avoided the pain of continuing chemotherapy. It is still controversial how to treat when tumor markers are progressively elevated. Based on clinical experience, it is very important to make a thorough evaluation, never scare yourself, and always consult an experienced physician for formal guidance and treatment. Current research has confirmed that H. pylori is inextricably linked to gastritis and gastric cancer. Whether it can be used as a target for the prevention and treatment of gastric cancer, and whether it can be a wind vane for our follow-up observation remains to be further researched and deepened. If there are similar patients, I hope they can keep in touch with me for long-term follow-up observation.