There are many reasons for frequent midnight coughs, which should be specifically analyzed and judged as follows: 1. Cough variant asthma: To exclude the presence of cough variant asthma, such coughs tend to be better or worse in the evening and early morning. Patients have a significant evening cough because of increased vagal excitability of the organism in the evening, which further increases airway sensitivity. Such patients need to improve tests such as bronchial excitation test and/or exhaled gas nitric oxide measurement to assess airway sensitivity for diagnosing the disease. 2. GERD cough: Midnight cough can also be seen in some patients with GERD cough. 3. Sleep apnea syndrome: Patients with severe sleep apnea syndrome wake up from suffocating in their sleep at night and experience significant snoring, which triggers their symptoms of 4. Heart failure: Some patients with heart failure have increased symptoms of wheezing and coughing when they sleep at night, so it is also important to identify them at this time.