1, palpable or non-fading lumps on the breast, skin, tongue, or any part of the body; 2, changes in warts or moles (deepening in color, rapid increase in size, itching, ulcers, bleeding); 3, persistent indigestion; 4, choking sensation when swallowing food, pain, stuffy discomfort behind the sternum, foreign body sensation in the esophagus; 5, tinnitus, hearing loss, nasal congestion, headache, blood in the nasopharyngeal secretions from aspiration and coughing; 6, menstrual period Unusual heavy bleeding, irregular vaginal bleeding outside the menstrual period or after menopause; 7, persistent hoarseness, dry cough, blood in sputum; 8, unexplained blood and mucus in stool or alternating diarrhea and constipation, unexplained hematuria; 9, long-standing wounds and ulcers; 10, unexplained weight loss for a longer period of time.