Pain medicine is an emerging discipline that many people do not know much about. In the traditional concept, people only know about internal, external, gynecological and pediatric medicine, but they simply do not know that pain medicine is also a medical discipline that can be directly examined, treated and prescribed. Experts remind patients that when pain symptoms appear, they should first choose to visit a pain department and not take painkillers at will, which will not only damage liver and kidney function and hematopoietic function, but also cover up certain major life-threatening diseases. There are patients with neck, shoulder and back pain who thought it was frozen shoulder, but later their condition worsened and they went to the pain department to find out the real cause was lung cancer, but they had missed the best time for treatment. The common intractable pains are mainly as follows: 1. trigeminal neuralgia: it is a recurrent transient and severe pain involving one or more distribution areas of the trigeminal nerve confined to the face. 2.Post-herpetic neuralgia: It refers to persistent and severe pain even after the lesions (scars) of herpes zoster have been completely healed. 3.Post-operative lumbar pain: It refers to the patient’s frequent lumbar pain even after spinal surgery for various reasons, when the primary disease has been removed. 4.Stubborn headache: the symptom of persistent headache for years and years. 5.Phantom limb pain: The subjective feeling that the amputated limb still exists, and the illusion of severe pain. For example, one side of the patient’s thigh has been amputated, but the patient feels that it still exists but with toe discomfort or pain. Treatment of pain: 1. Minimally invasive treatment system: Common methods include treatment by puncture positioning under the interventional guidance of C-arm X-ray machine or CT equipment to reach the lesion site. Minimally invasive treatment systems and equipment are available: ozone precision treatment system, radiofrequency thermal coagulation treatment system, plasma surgery system, etc. 2.Pharmacological treatment: including narcotic analgesics, non-steroidal anti-inflammatory drugs (NSAIDs) and combined analgesic programs through the addition and synergy of different analgesics to achieve adequate analgesia. 3.Nerve block and nerve destruction therapy: pain is treated by blocking the nerve conduction pathway of pain, and there are pain point block, peripheral nerve block, intradural block and sympathetic nerve block, etc. 4.Patient-controlled analgesia PCA and psychotherapy. 5, physical therapy: including massage, massage and the use of artificial physical factors of electrotherapy, ionizing air therapy, microwave electrotherapy, etc. 6.Electrical stimulation therapy: electrical stimulation to various levels of the nervous system can produce analgesic effect through the interaction mechanism of endogenous neuromodulation system at last. Commonly used methods include transcutaneous electrical nerve stimulation therapy (TENS therapy), transcutaneous acupoint electrical stimulation therapy (SPP therapy), epidural interstitial electrical stimulation therapy, etc. 7.Other: such as traditional Chinese medicine and acupuncture treatment.