Recently, Xiao Li suddenly developed chills, fever, general discomfort, left-sided tinnitus and ear pain. After an examination at the hospital, she was diagnosed with “acute suppurative otitis media”. After anti-infection and incision and drainage, her pain was greatly reduced and she was basically cured a week later. Why does purulent otitis media cause headache? It turns out that when acute middle ear inflammation occurs, purulent inflammation occurs in the mucous membrane of the ear cavity, and the exudate in the tympanic chamber accumulates and the pressure gradually increases, directly compressing the tympanic membrane and causing deep pain in the ear canal. In addition, if otitis media remains untreated for a long time, chronic sinus tracts can form, which not only involve adjacent tissues and structures, but also invade into the skull, often causing transverse sinus thrombosis, otogenic meningitis, otogenic brain abscess and so on. These lesions can either directly involve pain-sensitive structures in the skull and cause headaches, or they can lead to intracranial hypertension and cause high cranial pressure headaches.