The so-called creatine kinase high responder syndrome (creatine kinase high responder syndrome) is a significant increase in serum creatine kinase after mild exercise and other stresses, the magnitude of the increase is disproportionate to the intensity of stresses such as exercise load, and is more prone to rhabdomyolysis (rhabdomyolysis) than normal people. In recent years, dozens of patients were found to have been seen with symptoms such as weakness after low to moderate intensity training or exercise, and laboratory tests revealed a significant increase in serum creatine kinase, with the exception of common disorders such as heat stroke, hypothyroidism, dermatomyositis, polymyositis and other neuromuscular diseases, which were relieved by symptomatic treatment such as rehydration, and individual patients had a tendency to have recurrent attacks. In addition to the genetic type, it is assumed that there may be some abnormal response of muscle cells to creatine kinase permeability under stimulation such as exercise load, and glucocorticoid shock therapy has been tried with good results. Creatine kinase irritability syndrome is a special type of rhabdomyolysis in response to exercise and other stresses, manifesting as elevated creatine kinase induced by mild stimuli, without clinical manifestations of muscle necrosis such as fever and soy sauce urine, except for muscle pain, and myoglobin is rarely detected in blood and urine. In contrast, rhabdomyolysis usually refers to rhabdomyolysis caused by a variety of genetic or acquired diseases affecting the rhabdomyocyte membrane, membrane channels and their energy supply, due to changes in cell membrane integrity, leakage of cell contents, including myoglobin, enzymes such as creatine kinase, and ionic and small molecule toxic substances, and mostly due to severe irritation, with clinical manifestations associated with muscle necrosis, and often large amounts of blood and urine The clinical manifestations associated with muscle necrosis are often large amounts of myoglobin and other muscle necrotic substances in blood and urine; due to severe cell damage, intracellular potassium ions and phosphates are released into the blood, which can lead to fever, hyperkalemia, hyperphosphatemia, elevated blood uric acid and decreased blood calcium. Secondly, the enzymatic release “substrate” of creatine kinase irritable syndrome is the whole body muscle tissue, the mechanism of the whole body muscle cell permeability is abnormally high, there may be no change of cell integrity, so it often shows a significant increase of creatine kinase without obvious muscle necrosis; while the enzymatic release “substrate” of rhabdomyolysis ” can be a localized muscle tissue or involve the whole body muscle tissue, and the magnitude of creatine kinase elevation parallels the degree of muscle necrosis. The disease should also be differentiated from Haff disease, also known as lake disease, which is caused by a sudden onset of rhabdomyolysis within 24 hours of consuming seafood such as fish and crayfish, with an incubation period of about 6-8 hours; the etiology is unclear and is suspected to be related to an as yet undetermined toxin; the main manifestations are nausea, vomiting, abdominal pain, and muscle tenderness, rigidity, and soy urine, usually without febrile manifestations. Most have a good prognosis and recover quickly with prompt treatment; symptoms usually subside within 2-3 days, and those with milder symptoms may heal spontaneously without treatment. The clinicopathological process of the two is similar in many ways. Haff disease is an abnormal response of the transverse muscle after eating seafood, while creatine kinase irritable syndrome is an abnormal response of the transverse muscle after light exercise, and the two diseases are probably homologous. In conclusion, the clinical characteristic of creatine kinase irritable syndrome is a significant increase in serum creatine kinase after light exercise, the increase is disproportionate to the intensity of the exercise load, and such patients may not be suitable for high-intensity exercise, and should not be engaged in athletes, police officers, soldiers and other occupations closely related to sports.