Granulomatous granulomatosis, a general term for a class of benign diseases, is a collection of macrophages, T cells, and inflammatory cells accompanied by proliferation of surrounding fibroblasts, forming nodular lesions with relatively clear borders to distinguish lobulated, burr-like, and other irregularly bordered masses formed by malignant tumors. Causes of granulomatous inflammation include infectious granulomas, foreign body granulomas, etc. 1. Infectious granulomas: Common causative agents include bacteria such as Mycobacterium tuberculosis and Mycobacterium leprae, as well as fungi such as Mycobacterium longum, Pseudohyphae, and Cryptococcus. In addition, parasites, such as filarial worms and schistosomes, can cause local inflammation and the formation of encapsulated masses. 2. Foreign body granulomas: Granulomas may be caused by foreign bodies of endogenous origin in the human body, such as calcified deposits from tissue necrosis and the contents of ruptured tumors, or they may be caused by foreign bodies of exogenous origin, such as metal fragments, glass fragments, dust, etc. Due to long-term chronic stimulation of foreign bodies, it can lead to persistent inflammatory reactions in patients, resulting in proliferation of fibrous tissues and granulomatous granulomatous inflammation; 3. Other factors: It may be due to nodular diseases caused by disorders of the patient’s autoimmune system, such as Wegener’s granulomatosis, metaplastic vascular granulomatosis, and eosinophilic lymphogranulomatosis. The causes of granulomatous inflammation are widespread. Patients are advised to visit the hospital in a timely manner to improve the appropriate tests, such as blood tests and puncture biopsies, to determine the composition of the lesion through pathological biopsy and to distinguish such diseases from malignant neoplastic diseases. After identifying the cause of the disease, follow the doctor’s instructions for the appropriate treatment.