There are many different cases of stomach pain in the middle of the night every day: 1. It may be caused by duodenal ulcer, which causes stomach acid to stimulate the ulcer surface, so there will be obvious pain at night, but it can be effectively relieved after eating, because in the state of fasting, stomach acid will cause strong stimulation, so there is obvious pain, but after entering food it can effectively 2, may also be caused by gastrointestinal spasm, so at this time there will also be periodic stomach pain phenomenon, in order to effectively achieve the effect of relief, you should do gastroscopy to see what is caused by the cause, if necessary, you can choose acid suppressant drugs to achieve the therapeutic effect, should also be tested for H. pylori, and eradication.