The preference for cold and fear of heat is a clinical manifestation in the increased metabolism caused by excess thyroxine. The thyroid gland is a very important gland in vertebrates and is an endocrine organ. With the development of society and the continuous improvement of living standards, the thyroid gland is now rising among women, with an annual increase of 0.3% according to statistics. Diagnosis: 1, increased metabolic rate: manifested as hyperphagia, weight loss, accelerated heart rate, fatigue, coolness, fear of heat, warm skin, dampness and sweating, but also chest tightness and shortness of breath, diarrhea and loose stools. 2, nervous excitement: often manifested as hypersensitivity, nervousness, impatience, easily agitated, insomnia and dreaminess. In severe cases, mental disorders such as melancholy and mania may appear. In short, the diagnosis of this disease is not difficult, if the clinical manifestations of palpitations, spontaneous sweating, increased appetite and weight loss, emotional excitement, hand trembling, protruding eyes and enlarged thyroid gland, the initial diagnosis can be made.