1.Symptoms such as back pain, abdominal distension or abdominal mass, hematuria, etc.: immediately go to hospital for ultrasound examination of kidney and other abdominal internal organs. 2.No symptoms, kidney tumor found by ultrasound of physical examination: immediately go to hospital for kidney enhanced CT scan to clarify whether there is kidney tumor, tumor size, preliminary nature, involvement range, whether there is invasion of surrounding organs, whether there is lymph node metastasis, etc. Zhang Hailiang, Department of Urology, Cancer Hospital of Fudan University 3. CT clearly indicates the presence of kidney tumor, if it suggests malignancy, surgery is recommended; if the nature is unknown, MRI of kidney is recommended for further clarification. 4.After CT and MRI suggest malignant tumor, further whole body assessment examination, including lung CT, should be performed to exclude distant metastasis. 5. If the kidney tumor is less than 4cm and grows in the periphery of the kidney, partial nephrectomy can be considered to remove only the tumor and keep the kidney; if the size of the tumor is between 4-7cm, few patients can also keep the kidney and cut only the tumor, but most of them need radical nephrectomy. Both laparoscopic surgery and open surgery can be used. 6.If the size of kidney tumor is between 7-10cm, radical nephrectomy is recommended. Both laparoscopic surgery and open surgery can be used. 7.If the kidney tumor is larger than 10cm, accompanied by lymph node metastasis, or venous tumor thrombosis, etc., open radical nephrectomy is recommended, and laparoscopic surgery is likely to cause tumor dissemination. 8.After surgery, usually every 3-6 months, follow-up check-ups should be conducted, including blood sampling, liver and kidney function, blood count, c-reactive protein, abdominal ultrasound or CT, and plain CT of lung. 9.If the diagnosis is accompanied by lung metastasis or bone metastasis or other organ metastasis, the decision of whether to remove the kidney tumor first should be based on the ratio of metastasis volume to kidney tumor volume. If the metastasis volume is smaller than the kidney tumor, the kidney tumor should be removed first and then receive molecular targeted therapy as long as the patient’s physical condition can tolerate the surgery. For patients with metastatic foci smaller than kidney tumor, kidney tumor puncture biopsy should be performed first, and molecular targeted therapy should be used first according to the pathological results of the puncture. 10.Molecular targeted therapy for metastatic kidney cancer patients is lifelong, and the drugs are purchased at their own expense in the early stage, and the subsequent drugs are provided free of charge as long as the treatment is effective, but they need to pass the approval of China Charity Federation or China Cancer Foundation, and the approval rate is usually above 90%. 11.In the early stage of targeted therapy, you need to check blood routine and liver and kidney function every 1-2 weeks, and CT or MRI of metastatic area every 4-6 weeks, and review CT or MRI of metastatic area 2-3 months after getting the free drug.