There are many similarities between the clinical manifestations of Meige syndrome (Meige’s syndrome) and facial myasthenia, leading to confusion in diagnosis for many physicians and patients, thus causing confusion in treatment. Clinically the two have some similarities in common: both disorders present with involuntary frequent blinking and twitching of the facial muscles. The difference between the two: facial myasthenia gravis is usually unilateral eyelid fluttering or twitching, frequent blinking, accompanied by involuntary twitching of the ipsilateral mouth, face or neck muscles, with paroxysmal episodes of twitching and irregularity; the symptom is more affected by emotions, and twitching is more frequent when tired, nervous or emotionally excited. Usually, facial spasms are limited to one side of the face, and thus are also called hemifacial spasms. In Meige’s syndrome, the first symptom is bilateral blepharospasm, with early onset of dry eyes, itchy eyes, frequent blinking, and difficulty opening the eyes as the disease progresses. In general, there are no significant intervals between blepharospasms in Major’s syndrome, and ptosis and eyelid weakness are also common. It is often misdiagnosed as “dry eye” or “myasthenia gravis”. In some patients, the disease starts in one eye and gradually spreads to both eyes. Bilateral eye symptoms are aggravated by fatigue, sunlight stimulation, gaze, and stress. As the disease progresses, the symptoms of twitching begin to develop gradually down the face, showing symmetrical, irregular and hyperactive contraction of the oral and mandibular muscles, manifesting as pouting, lip reduction, cheek biting, tooth contusion, tongue retraction, tongue twisting, etc. The tension of the mandibular muscles may also prevent chewing, swallowing and speaking, and when the laryngeal and respiratory muscles are invaded, there may be spasmodic dysphonia, dysphagia and dyspnea. A characteristic clinical phenomenon of Meijer syndrome is the dramatic reduction or disappearance of symptoms when the patient yawns, eats, coughs, sings, plays the piano, quizzes, plays the harmonica, or plays the mouth flute, which is called the “Tricks” phenomenon.