If a diabetic patient develops pinprick pain in the toes, it is usually neuralgia or diabetic foot caused by peripheral neuropathy due to this disease, but it can also be caused by other diseases not related to diabetes, such as gout. Peripheral neuropathy is a common complication of the disease, the reason for this performance is that diabetic patients with poor glycemic control, lesions in the lower limbs, and often bilateral symmetric attacks, early manifestations of sensory abnormalities, such as toes and other nociceptive allergy, that is, the patient consciously feel pain in the toes pinprick sensation, and the later may be the disappearance of the sensation. In addition, diabetic patients due to lower extremity distal nerve abnormalities and peripheral vascular disease caused by diabetic foot, can also appear to the toes pins and needles pain, this is another serious complication of the disease, can also be accompanied by foot ulcers, infection, deep tissue destruction and other manifestations. It should be noted that diabetic patients with simple pain in the toes, may also be caused by other diseases not related to diabetes, such as toe trauma, gout, peripheral neuritis. Therefore, diabetic patients with this symptom, need to pay attention to timely consultation, under the guidance of the doctor for regular blood glucose testing and treatment, treatment is not timely or aggravation of the condition may also have the possibility of amputation.