With the development of society and the increase of people’s health awareness, annual health checkups have become popular to most people. There are often patients who come to the outpatient clinic for review with the physical examination report, wondering whether the nodules in the liver described by imaging are important or not? Could it be liver cancer? Do they need to be treated? Some of them go to Baidu to search for their own nodules, but the more they search, the more scared they are, and the more uncertain they are. First of all, let’s have a brief understanding of what role the liver plays in our body. The liver is the largest digestive gland in the human digestive system, located in the upper right abdomen of the body, weighing about 1200g. It is involved in metabolism, bile production, detoxification, blood clotting, immunity and other important functions of the human body, and is an important organ indispensable for maintaining human life activities. I. Intrahepatic nodules It is a collective term for lesions that occur in the liver area and can be divided into two categories: benign and malignant. Benign nodules commonly include liver cysts, hepatic hemangiomas, and focal nodular hyperplasia. They generally grow slowly and have little impact on human health, so they do not require special treatment and usually only need regular follow-up. However, if the nodules are too large and cause pressure symptoms, surgery may be considered. Malignant nodules are also commonly referred to as malignant tumors. They mainly include hepatocellular liver cancer, cholangiocellular liver cancer, metastatic tumors of the gastrointestinal tract, gallbladder, breast, etc. Malignant tumors are infiltrative growth, rapid growth, easy to metastasize, and are very dangerous to life. It must be treated as early as possible after detection and should not be delayed. Ultrasonography is the preferred method of liver imaging, which is inexpensive, convenient and non-invasive. Routine ultrasonography recommends that patients fast for more than 8 hours to reduce the effect of gastrointestinal gas on the image quality of the liver. Conventional ultrasound can show the size and shape of the liver, the parenchymal structure of the liver, the duct system, the direction and distribution of blood vessels, clarify the presence or absence of liver nodules, the specific size and location, and initially identify the benign and malignant nature of nodules, which is suitable for routine physical examination and regular review of nodules. Ultrasonography Although conventional ultrasound is the preferred method of liver examination, further qualitative diagnosis of intrahepatic nodules and clarification of nodule blood supply require the assistance of ultrasonography. Ultrasonography is performed by intravenous injection of ultrasound contrast. It is suitable for lesions that require further definitive diagnosis after conventional ultrasonography, for suspicious lesions in patients with chronic hepatitis or cirrhosis, for suspicious lesions in patients with a history of malignancy, and for additional imaging information when MRI, CT or other imaging results are not clear or the results are inconsistent. 4. Why is there no symptom normally when intrahepatic nodules are found in physical examination? There are no obvious symptoms in the early stage of benign and malignant nodules in the liver. Some oversized benign nodules may have discomfort in the right upper abdomen when they produce pressure symptoms. Once there are obvious symptoms such as swelling and pain in the liver area, lump in the upper right abdomen, unexplained weight loss, bloating, diarrhea, intermittent fever, and weakness, it is already in the advanced stage. Therefore, regular medical checkups are very important, such as “I do not have any discomfort, so I do not need to check” idea should not be. Who are prone to malignant nodules (malignant tumors)? The occurrence of malignant tumors usually has a certain basis in liver disease. Family history of liver cancer, chronic hepatitis B patients, patients with cirrhosis and previous history of tumor are all high-risk groups, which need to be reviewed regularly at the hospital. In conclusion, for liver nodules described in the physical examination report, patients also need to go to the hospital for re-examination. After clarifying the benign and malignant, differentiate them: benign nodules are checked regularly, malignant nodules are treated early.