The large hole that appears after the patient squeezes out the blackhead is the enlarged follicular opening, and the enlarged follicular opening is irreversible and usually cannot be completely restored, but it can be improved by medication and physical therapy.1. Medication: If the patient’s enlarged follicular opening is not obvious, vitamin C and vitamin E can be applied locally for improvement; if the enlargement is more obvious, topical adapalene gel can usually be used under the guidance of a doctor for The treatment can promote normal keratinization of the stratum corneum, inhibit acne formation and repair the follicular opening. However, when using adapalene, patients may experience redness, tingling and peeling of the skin, which may disappear after a few days and can be used normally when the skin tolerates it. In addition, patients can also use topical moisturizing and repairing drugs, such as hyaluronic acid gel, to protect the skin barrier and thus repair the enlarged follicle mouth; 2, physical therapy: physical therapy can be used when the effect of drug treatment is not good, patients can go to the regular hospital through photorejuvenation and other physical therapy, using specific broad-spectrum color light directly on the skin surface, penetrating to the deeper layers of the skin, stimulating the growth of subcutaneous collagen and fibroblasts This stimulates the growth of collagen and fibroblasts under the skin, further promoting the growth of the hair follicle opening, thus achieving the effect of restoring the hair follicle opening. Carbon dioxide fractional laser, intense pulse light and other methods can have similar effects.