Blisters on the tongue are usually caused by mouth ulcers, tongue burns, etc. If the pain is unbearable and even affects eating, lidocaine gel or benzocaine gel can be applied to the affected area under the guidance of a doctor as appropriate, which can provide rapid anesthesia and pain relief, but should not be used multiple times to avoid addiction. In addition, if blistering of the tongue is caused by burns, cold water or ice can be immediately administered orally to relieve pain. Common clinical measures include: I. Tongue ulcers: 1. Anti-inflammatory drugs: Compound borax solution can be used for gargling, which can play an anti-inflammatory role. You can also apply tretinoin oral ointment and other drugs on the affected area, which helps the ulcer surface to heal; 2, vitamin drugs: oral vitamin B, vitamin C, vitamin E, etc., can promote the growth of epidermal cells, which is conducive to ulcer recovery; 3, zinc-containing drugs: as zinc deficiency can lead to the occurrence of tongue ulcers, the condition can improve after zinc supplementation, commonly used drugs include zinc sulfate syrup, zinc gluconate and other preparations. Second, tongue burns: 1, general treatment: if the blisters are small after the burns can not be treated, daily avoid using the affected side of the teeth chewing can be. If the blisters are too large, too much can be picked up at the hospital to break the blisters, avoid self-treatment; 2, antibiotics: appropriate oral antibiotics can be taken according to medical advice to prevent secondary infection, commonly used drugs including ceftazidime, amoxicillin, etc.; 3, hormonal drugs: if necessary, drugs such as dexamethasone can be given to reduce swelling. In addition, herpes simplex virus infection causing herpes on the tongue with pain should be considered. Glucocorticoids and antiviral drugs need to be applied under the guidance of a doctor for treatment in order to gradually relieve the symptoms.