1.What foods will affect anticoagulation? Foods rich in vitamin K will make the anticoagulant effect of warfarin decrease, these foods are mainly: Poached vegetables, cabbage, capers (ground vegetables), kale, carrots, egg yolk, pig liver, green tea, etc.. Among them, green leafy vegetables have higher vitamin K content, such as: spinach, leek, rape up to 236-436μg/100g, cabbage medium for 89μg/100g, celery stems, radish, cauliflower, cucumber less content for 30-40μg/100g (cucumber skin content is high, should be peeled and eaten), and tomatoes at least only 5μg/100g. In addition, natto contains natto Bacillus subtilis, which can produce large amounts of vitamin K in the intestine, makes warfarin anticoagulant effect reduced. There are also foods that reduce the anticoagulant effect of warfarin by other means. Avocados can induce liver-related drug metabolizing enzyme activity and promote warfarin metabolism, while interfering with the absorption of warfarin in the intestine, thus reducing the anticoagulant effect of warfarin. Soy milk and seaweed weaken the anticoagulant effect of warfarin by altering its metabolism and affecting its absorption. Some foods can enhance the anticoagulant effect of warfarin. For example, the combination of garlic and ginger with warfarin can increase the anticoagulant effect of warfarin. Grapefruit contains coumarins, which also inhibit the activity of liver-related drug metabolizing enzymes, reducing the metabolism of warfarin and enhancing its anticoagulant effect. Mango contains vitamins A, C, B1, B6, etc., which can also enhance the anticoagulant effect of warfarin when combined with it. Fish oil enhances the anticoagulant effect of warfarin by inhibiting platelet aggregation and reducing the levels of coagulation-related thromboxane and vitamin K-dependent coagulation factors. Although there are so many foods that affect anticoagulation, however, studies have shown that occasional intake of large amounts of vitamin K-rich foods does not significantly affect the anticoagulant effect of warfarin, and only continuous consumption of large amounts of related foods for more than a week (e.g., daily consumption of spinach at half a pound per day for more than a week) can significantly reduce the anticoagulant effect of warfarin. Therefore, we can conclude that: 1, the relevant food can be eaten, but do not eat a large number of daily; 2, forced to eat the relevant food every day, you need to check the INR diligently and adjust the warfarin dose in a timely manner. 2.What drugs affect anticoagulation? There are many drugs that affect anticoagulation, so let’s name them in general. First of all, there are drugs that can enhance anticoagulation: aspirin, acetaminophen (paracetamol), amiodarone, pautazone, methotrexate, clobetasol (Antomin), tetracycline, sulfonamides, propofol, chloramphenicol, allopurinol, monoamine oxidase inhibitors, metronidazole (methotrexate), fluconazole, miconazole, itraconazole, omeprazole, indomethacin, cimetidine, azithromycin, erythromycin Clarithromycin (methomycin), doxycycline, cephalosporins, nalidixic acid, ciprofloxacin, norfloxacin, ofloxacin, isoniazid, lodetate, gemfibezil, clobetine, propafenone, liquid paraffin, quinidine, levothyroxine, phenylephrine, salicylates, chlorpromazine, diphenhydramine, streptokinase, urokinase, heparin, etc. Next are drugs that attenuate anticoagulation: acidophilus, cathepsin, ashwagandha, neomycin III, antipyrine, carbamazepine, barbiturate, pentobarbital, phenobarbital, isopentobarbital, isobutalbital, rifampin, grumet (conduction sleep energy), meprobamate (anine, sleeper), abortifacient, aluminum thioglycollate, azathioprine, cyclosporine, trazodone, vitamin K, oral contraceptives, estrogen, etc. . Herbs that can enhance the anticoagulant effect include: Danshen, Chuanxiong, safflower, peach kernel, motherwort, turmeric, curcuma longa, leech, cinnamon, frankincense, yanhuosuo, tulip, tiger scepter, jing sanling, chicken blood vine, red peony, wang bu liu xing, etc. The Chinese medicines that can weaken the anticoagulant effect are: ginseng, American ginseng, Diyu, Phellodendron, Bupleurum, Blood remaining charcoal, Lotus root, Little thistle, Phellodendron, Dragon’s tooth grass, Fairy crane grass, Palm, Cyperus, Ramie, White foxglove, Sophora japonica, and Prickly spurge. Although so much has been introduced, the most common concern is: Is it possible to take cold medicine? Cold medicines often contain acetaminophen, which is also known as paracetamol, such as Benadryl and Tylenol contain this ingredient, a large number of prolonged use will have a certain impact on anticoagulation; in addition, the cold itself can also affect anticoagulation by changing the body’s metabolism of warfarin; therefore, cold medicines can be taken in small doses when you have a cold, while paying attention to the impact of drugs on anticoagulation, appropriately increase the INR test The number of INR tests should be increased, and warfarin dosage should be adjusted if necessary. In addition, some of the “tonic” drugs are rich in vitamin K, such as Sinclair and Silcon, which can reduce the anticoagulant effect, which is also worth noting.