In non-emergency situations, it is not recommended that the New Crown vaccine be given at the same time as the Hepatitis B vaccine. The New Crown vaccine should generally be considered 2 weeks after all three doses of the hepatitis B vaccine have been administered. In emergency cases, consult with the relevant medical staff before determining whether or not you can receive the New Crown vaccine. On the one hand, the New Crown vaccine has not been used for a long time, and the relationship between the New Crown vaccine and other vaccines, and whether there is any interaction between them, has not been fully studied, so it is not recommended that the New Crown vaccine be given at the same time as other vaccines. On the other hand, hepatitis B vaccination may cause redness, swelling, itching or hard nodules at the vaccination site, and may also be accompanied by adverse reactions such as fever, nausea, loss of appetite, depression and diarrhea, similar to those of the New Crown vaccine. If the above-mentioned adverse reactions occur, it indicates that there may be a mild allergy, and it cannot be excluded that there may also be an allergy to the ingredients in the New Crown vaccine, and the simultaneous vaccination will aggravate the adverse reactions. In conclusion, it is not recommended to administer hepatitis B vaccine and New Crown vaccine at the same time in non-emergency situations. In emergency cases, the best choice should be made by explaining the situation to the relevant medical staff before administering the New Crown vaccine.