Steve Jobs died of a neuroendocrine tumor

  The cause of the death of Steve Jobs, one of the founders of Apple, has become the focus of media attention, with many media claiming that Jobs died of pancreatic cancer. In fact, the results of the investigation published by the American media showed that Jobs was suffering from a neuroendocrine tumor (NET), which just happened to be located on the islet cells of the pancreas, not pancreatic cancer. Jobs also pointed out during his lifetime, “The remaining life of a pancreatic cancer patient is usually very short, and very fortunately, what I have is not pancreatic cancer.”  Neuroendocrine tumors originate from endocrine cells in the human nervous system and are “hybrids” of endocrine cells and nerve cells. Neuroendocrine cells are found in the body’s lungs, gastrointestinal tract and other organs and perform specific functions, such as regulating airflow and blood flow through the lungs and controlling the speed of food through the digestive tract. NET has a different course and prognosis than pancreatic cancer.  Early diagnosis of NET is very difficult, and the International Congress of Neuroendocrine Tumor Specialists held in Washington, D.C. in 2007 noted that all types of neuroendocrine tumors are far more prevalent than various rare cancers, including pancreatic cancer, but they receive far less attention than pancreatic cancer.  Islet cell tumors are neuroendocrine tumors, whereas pancreatic cancer is an adenocarcinoma of the digestive system. Islet cells are scattered in the pancreas to secrete hormones such as insulin, glucagon, growth hormone, and inhibitory hormone, and its function is to regulate a person’s blood sugar, and if the islet cells are inflammatory and secrete insulin abnormally, hypoglycemic symptoms will occur. And the glands in pancreatic cancer mainly secrete fluid, which is involved in digestion and decomposition of food through digestive juices, etc.  The foci of neuroendocrine tumors are not necessarily in islet cells, but other organs like adrenal cortex and pituitary gland may become cancerous, and they are collectively called neuroendocrine tumors, which have a high total incidence, but the relative number of those occurring in the pancreas is small, but adults and children may become patients. Zhang Guangchao said that islet cell tumors may be malignant or benign, and there is not much difference between the two in terms of pathological structure, but in terms of clinical symptoms, tumors localized in the pancreas are benign and can be solved by surgical resection; however, if they are metastatic, multiple or advanced, it is difficult to cure them.