Recently, Mr. Zhao had a toothache when he exercised or was in a hurry, and it did not get better even after taking painkillers. As a result, he was found to be suffering from coronary heart disease when doing a comprehensive examination, and the toothache gradually disappeared after taking coronary heart disease treatment drugs. Mr. Zhao is very puzzled: “It is said that coronary heart disease signals are heart pain, panic, chest tightness, shortness of breath, I do not have these symptoms ah? Is toothache also a sign of coronary heart disease?” Chest pain, panic, palpitations, chest tightness and shortness of breath after exertion, emotional excitement or a full meal are relatively common signals of coronary heart disease, and we all know them better. However, there are some manifestations that are less connected to the heart, and people may ignore them, such as toothache. The heart itself has no pain nerves. Once the heart muscle is ischemic due to coronary heart disease, it will accumulate a lot of metabolites, such as lactic acid and other substances. These metabolites stimulate the vegetative nerves of the heart, the stimulation signal is transmitted to the spinal cord center through the vegetative nerves, the incoming spinal cord segments can be slightly different from person to person, and the spinal cord center at the same time accepts the incoming signals from the somatosensory nerves, when the spinal cord center receives the stimulation signals from the vegetative nerves of the heart, in the process of processing, it will mistakenly think that it is a signal coming from the somatosensory nerves of the corresponding parts of the body, and it feels discomfort in these parts, at this time, it is time to stimulate the heart. When the spinal cord center receives the stimulation signal from the cardiac vegetative nerve, it will mistake it for the signal from the corresponding somatic sensory nerve during processing and feel the discomfort in these parts, and it depends on the part of the body to which the stimulation signal is transmitted. Since the afferent segment of the cardiac vegetative nerve is usually the afferent segment of the sensory nerve of the left chest and the left upper limb, the majority of patients with coronary heart disease will have the manifestation of pain in the left chest or the left upper limb. Similarly, if the afferent segments are low, it may manifest as epigastric pain and be mistaken as a symptom of gastrointestinal disorders, and in some cases, it may manifest as shoulder and back pain. Therefore, if the symptoms of pain in the above areas occur in the presence of physical activity, full meals, cold air stimulation, emotional changes; and this pain will disappear within a few minutes after the disappearance of the trigger, then this is likely to be a signal of coronary heart disease. People with such signals should go to the hospital as soon as possible to receive a comprehensive examination, to tell the doctor about the symptoms. If it is really coronary heart disease, it should be treated as soon as possible. In fact, the medical angina is not necessarily the real “pain”, in the above triggers under the role of chest tightness, shortness of breath, dyspnea, pressure, tightness, or other indescribable feeling of discomfort, if the onset of triggers, duration, and ways to relieve the angina symptoms in line with the characteristics of angina pectoris, but also diagnosed as angina pectoris! All of these symptoms are called angina equivalents. If angina pectoris or its equivalent symptoms have occurred within the last month, or if the pattern of symptoms has changed significantly within the last month, or if there is a significant decrease in activity tolerance, or if the symptoms occur at rest, this is called ‘unstable angina’, and requires high priority and prompt medical attention.