Low progesterone infertility consists of two broad aspects. On the one hand, women can’t conceive a child, can’t get pregnant, accompanied by low progesterone, on the other hand, women can be fertilized, but can’t get pregnant normally to full term production, low progesterone in every pregnancy, followed by embryonic abortion and miscarriage, these two should be treated differently. First, low progesterone can not get pregnant: for low progesterone can not get pregnant, generally clinically considered luteal insufficiency, on the one hand, affect the quality of egg cells, on the other hand, affect the fertilization of eggs. Luteal insufficiency usually affects ovulation, which may include follicular dysplasia, poor maturation or ovulation disorders that prevent the discharge of egg cells, all of which can affect sperm and egg union. If normal fertilization is not possible, this can lead to infertility in women. After ovulation, the ovaries form the corpus luteum, which secretes estrogen and progesterone to thicken the endometrium. If the corpus luteum is not fully functional, the endometrium is thin, which is not conducive to embryo implantation and sometimes leads to infertility. If the examination determines that there are no other gynecological inflammatory diseases and no other endocrine diseases, luteal phase progesterone supplementation treatment can be given, and through such treatment, some women can gain the ability to conceive. Second, low progesterone after pregnancy: sometimes women can get pregnant, but each pregnancy will have low progesterone, followed by embryonic abortion and miscarriage, which is called habitual miscarriage. Habitual miscarriage should be treated by finding the cause, sometimes it is due to the quality of the embryo itself, sometimes it is related to chromosomal abnormalities of both parents, sometimes it is related to autoimmune diseases of the mother or ovarian insufficiency. If the problem is the quality of the embryo, only another pregnancy can be carried out, because sometimes a poor quality embryo can cause a miscarriage. If it is caused by chromosomal abnormalities in both parents, it is recommended that the pregnancy outcome can be improved by taking a third generation IVF to select chromosomally normal embryos for implantation in another pregnancy. If it is associated with luteal insufficiency of the mother’s ovaries, it will show low progesterone and low progesterone, and the pregnancy can be treated with large amounts of progesterone supplementation to preserve the pregnancy. If associated with autoimmune diseases such as antiphospholipid syndrome, antiphospholipid syndrome can cause microthrombosis in the embryo, which often leads to low progesterone and eventually to embryonic abortion, usually followed by anticoagulation therapy after the next pregnancy.