Acute urethral syndrome, also known as “aseptic dysuria-dysuria syndrome”, refers to patients who have only symptoms of urinary frequency, urgency and/or painful urination, and who have a negative quantitative culture of midstream urine bacteria. Patients can be divided into two categories: 70% of patients have true urinary tract infections, some of which are symptomatic inflammation caused by urinary tract tuberculosis, fungal infections, or rare intra-abdominal or renal pelvis infections, but most patients are infected with Chlamydia trachomatis or common bacteria (low number, 102-104 /ml); the remaining 30% of patients do not have pyuria, the etiology of which is unknown and may be related to trauma caused by sexual intercourse, local irritation, topical contraceptives It may be related to trauma caused by sexual intercourse, local irritation, topical contraceptives, allergy to organic fibers and dyes on underwear, etc. It should be treated according to the pathogen, with a duration of 7-14 days and 6 weeks for recurrences. The disease may also be part of the symptoms of anxiety neurosis, taking Valium 2.5mg 3 times a day or Glutathione 10mg 3 times a day is helpful to reduce the symptoms.