What is the problem of high blood uric acid and what are the dangers? High uric acidemia and gout are mostly found in coastal areas, but now they are gradually developing inland, and the age of onset is getting lower and lower, which brings more and more influence and troubles to our body and life. So what is hyperuricemia all about? First of all, let’s see what is uric acid? Uric acid is the end product of purine metabolism in humans. Under normal circumstances, the body has about 1200 mg of uric acid, the daily production and excretion is about equal, the body is in a relative balance. If the body produces too much uric acid or the excretion of uric acid is impaired, it will lead to retention of uric acid in the body. It is generally believed that hyperuricemia can be identified when men have >420umol/L and women have >350umol/L. Second, what are the causes of elevated uric acid? 1. Excessive production of uric acid in the body: about one-third of uric acid comes from food (exogenous), and two-thirds is synthesized by the body itself (endogenous). Excessive uric acid production can be divided into two categories: primary uric acid elevation is caused by excessive synthesis of uric acid, or the rapid synthesis of purines composed of uric acid due to enzyme defects in the body; secondary uric acid elevation is mostly seen in blood diseases, tumors, burns, etc., resulting in a large number of nucleic acid decomposition in the body. 2, uric acid excretion is reduced: one third of uric acid in the body is excreted by the biliary tract and intestines, and two thirds is excreted by the kidneys. Excretion disorder is divided into primary, secondary and mixed type: (1) primary is mostly idiopathic or hereditary; (2) secondary is mostly seen in renal dysfunction, dehydration, hyperthyroidism, acidosis, etc.; (3) mixed type: mostly seen in alcoholism, obesity, high purine, high calorie diet, after strenuous exercise, etc. Third, what are the dangers of hyperuricemia to human body? 1, uric acid in the human blood concentration is too high, soft tissues such as joint membranes or tendons in the formation of needle crystals, resulting in the body’s immune system overreaction, which causes inflammatory reaction, and then cause gout. 2, uric acid crystals to the kidney, ureter, bladder easy to form stones. If the excess uric acid in the body is crystallized as urate in the renal pelvis, ureter or precipitated in the renal tubules and interstitial kidney, forming kidney stones. 3, in addition to stones, hyperuricemia also leads to acute and chronic uric acid nephropathy. Some studies have shown that hyperuricemia itself is an important risk factor for aggravating the progressive development of various primary and secondary kidney diseases. Hyperuricemia is also associated with the development of renal hypertrophy, renal function damage, glomerulosclerosis and interstitial fibrosis. 4. There is also a close relationship between increased blood uric acid and the occurrence of cardiovascular disease. Some studies have reported that for every 1 mg/dL increase in blood uric acid (i.e. 60umol/L), the risk of coronary heart disease increases by 48%, and blood uric acid level >6 mg/dL is an independent risk factor for coronary heart disease, and blood uric acid level >7 mg/dL is an independent risk factor for stroke. 5. Hyperuricemia is often complicated with hypertension, hyperlipidemia and obesity, and is also a risk factor for these diseases. Although the increase of blood uric acid may cause so many diseases, but as long as we correctly understand and correctly treat hyperuricemia, we will prevent the occurrence of these diseases, for our physical and mental health, to regularly monitor uric acid, have to prevent oh.