Polycystic ovary syndrome (PCOS) is a common gynecologic endocrine and metabolic disorder in women of reproductive age. Typical clinical features include sporadic menstruation, amenorrhea, infertility, hirsutism, obesity and polycystic ovarian changes. Many patients with PCOS who visit our clinic often ask us, “Doctor, is my PCOS serious?” Here we give you some answers to your doubts! In the opinion of PCOS patients, the most worrying question is whether they can still have children in the future if they have this disease. In fact, from our doctor’s point of view, except for watery or blocked fallopian tubes, male partner’s weak sperm and sperm deficiency, immunity and other related factors causing infertility, most PCOS patients can successfully conceive after standardized treatment of androgen lowering, ovulation promotion, ovulation monitoring and guided intercourse. Therefore, pregnancy is not the most worrying problem of this disease. However, most patients are not aware that PCOS is often combined with various long-term complications, which have to be taken seriously by PCOS patients. 1, insulin resistance, diabetes The risk of insulin resistance and diabetes in PCOS patients is 3 to 7 times higher than in healthy women. Both thin and fat PCOS women are prone to insulin resistance and diabetes, and the risk and degree of insulin resistance occurring in obese PCOS patients will be more severe than in PCOS patients with normal body fat. This means that if we do not pay attention and take interventions now, we may join the ranks of the diabetic in the near future. Therefore, PCOS patients should improve their diet and lifestyle habits, exercise more, eat more vegetables and protein, avoid eating foods high in sugar and fat, and even need to cooperate with drugs to improve insulin function and regulate blood sugar levels. 2, obesity, cardiovascular disease about 50% of women with PCOS are obese patients, mostly centripetal obesity. Obese women with PCOS are more likely to have menstrual disorders, infertility, poor response to ovulation treatment, miscarriage, abnormal fetal development, abnormal liver function, fatty liver, hyperuricemia and pregnancy-related complications. In addition, obesity, hyperlipidemia, insulin resistance, and androgen excess increase the risk of cardiovascular diseases such as hypertension and coronary heart disease. For obese PCOS patients, weight loss can improve our menstruation, fertility, and future quality of life. Therefore, weight loss is a priority! 3.Endometrial cancer PCOS patients who do not have menstruation for a long time need to pay attention to the fact that due to sparse ovulation, the endometrium is stimulated by a single estrogen for a long time, which will lead to hyperplasia or atypical hyperplasia, and even cancer may occur. Currently, the incidence of endometrial cancer has tended to be younger, and some patients already have endometrial precancerous lesions or even endometrial cancer in their 20s. Therefore, we need to manage and restore our menstruation regularly. I believe that after giving you some information about the complications that can be caused by PCOS, you have a basic understanding of the seriousness of this disease. In fact, most of the patients who come to the clinic with menstrual sporadic problems need to exclude other diseases that cause menstrual disorders, such as abnormal thyroid function, hyperprolactinemia, primary hypovarianism or premature ovarian failure, functional hypothalamic amenorrhea, congenital adrenal cortical hyperplasia, androgen-secreting tumors of the ovaries or adrenal glands, in addition to the possible PCOS patients. So, what tests do we need to complete in the outpatient clinic in order to make a clear diagnosis and fully evaluate the condition? Endocrine 6, androstenedione, dehydroepiandrosterone sulfate, sex hormone binding protein, 17α hydroxyprogesterone, insulin release test (to determine the presence of combined insulin resistance), glucose tolerance test (to determine the status of blood sugar), thyroid function, liver and kidney function, blood lipids, transabdominal or transvaginal ultrasound, etc. If necessary, hysteroscopy is usually performed on the 2nd to 5th day of menstruation. It is best to have your blood drawn between 8:00am and 9:00am.