Hemorrhoids and cancer are two different things, and there are certain other comorbid factors if hemorrhoids become cancerous. Hemorrhoids are generally not cancerous in terms of their mechanism of development. This is because hemorrhoids are a type of vein tumor, or venous mass, in which the venous plexus in the wall of the rectal-anal area is dilated, curved, and elevated into a mass. In contrast, cancerous masses are formed by excessive proliferation due to immature cell differentiation. There are essential differences in the pathology and its clinical manifestations. However, some patients with hemorrhoids can be seen clinically with combined rectal or colon cancer, which is mostly due to malignancy of the affected area itself and is not related to hemorrhoids. In rare cases, hemorrhoids become cancerous, often as a result of mucosal erosion, long-term infection, recurrent episodes, or even the combination of perianal abscesses and anal fistulas, which remain untreated for a long time and are combined symptoms of hemorrhoids. It is thus clear that hemorrhoids themselves cannot induce cancer. However, if the nucleus itself is irritated by inflammation for a long time, or if it is not handled properly, it can produce different degrees of pathological changes, so it should be taken seriously. There are no reports of cancer in the hemorrhoid nucleus alone, so patients do not need to be alarmed and talk about cancer when they talk about blood in the stool or find a small lump of flesh at the anal opening. Nor should you take it lightly, thinking that hemorrhoids are irrelevant, thus putting your life at risk.