In recent months, two patients with huge submucosal esophageal tumors were seen consecutively, both presenting with difficulty in eating. Gastroscopy revealed the following submucosal tumors growing at the entrance of the esophagus: a. The length of the tumor was 15-20 cm, and the diameter was 4-5 cm. b. Both patients delayed the treatment for a long time due to financial problems, and did not seek medical attention until the tumor significantly affected eating. In the past, such a tumor could only be operated openly by thoracic surgery, but because a mass growing at the entrance of the esophagus may require a combined cervicothoracotomy, the operation is difficult and the complication rate is very high. After collective discussion in thoracic surgery, it was still suggested that Director Lu Zhongsheng should remove the tumor under endoscopy and surgery should do the safeguard. Despite the high location, small operation space and abundant blood vessels, both patients were successfully cut free from the tumor root by ESD technique. However, because the tumor was too large and hard in texture, it could not be removed completely through the mouth. Part of the tumor was removed in pieces and recovered for pathological examination, and the remaining tumor had already entered the stomach for digestion after a week of review. Through this minimally invasive endoscopic treatment, the patient’s esophagus remained intact and the quality of life was not affected. The trauma and risks of surgery were avoided and medical expenses were saved. The patient himself and his family benefited greatly.