Chest tightness and breathlessness, gripping pain may be caused by cardiovascular diseases, digestive system diseases and so on. 1. Cardiovascular disease: common angina, myocardial infarction and other diseases will appear chest tightness, breathlessness, heartburn symptoms. At this time, mainly by taking nitroglycerin or surgery to remove the thrombus, thrombolysis and other methods of treatment. In addition, heart failure can also cause the above symptoms, through the use of diuretics such as furosemide, spironolactone, etc.; cardiotonic drugs such as digoxin, cediran, etc.; vasodilator drugs such as sodium nitroprusside, nitroglycerin, etc.. 2. Digestive system diseases: common gastroesophageal reflux disease will appear chest tightness and breathlessness, heartburn and other symptoms, acid reflux, heartburn and so on. At this time through the use of proton pump inhibitors such as omeprazole, ranitidine, etc. to relieve the above symptoms. To go to the hospital as soon as possible, improve the relevant examination such as gastroscopy, cardiac ultrasound, etc., to clarify the cause of the disease. The above mentioned drugs should be taken under the guidance of professional doctors.