Platelet volume in routine blood tests refers to mean platelet volume (MPV), which is the average value of platelet volume in the body. The presence of a mildly low mean platelet volume alone, with no other disease or discomfort, may be due to physiological causes and does not require specific treatment. When the platelet volume is severely low, it may be related to hematopoietic dysfunction, bleeding disorders and chemotherapy toxic side effects. 1. Hematopoietic dysfunction: It is common due to abnormal bone marrow hematopoiesis leading to aplastic anemia, leukemia and other diseases, which may lead to a reduction of hematopoietic stem cells in the body, resulting in low platelet volume in the body. Immunosuppressants, such as cyclosporine, and drugs that promote hematopoiesis, such as androgens, can be used as prescribed by the doctor to help raise the platelet volume. 2. Bleeding disorders: When the body has bleeding disorders such as gastrointestinal bleeding due to disease, low average platelet volume may occur. The bleeding should be promptly treated with drugs, such as posterior pituitary hormone, and targeted treatment for the site and cause of bleeding, such as the use of ligatures to stop bleeding; 3, chemotherapy toxic side effects: patients with malignant tumors and other diseases may experience damage to the body’s hematopoietic stem cells during chemotherapy. This may lead to the normal hematopoietic function of the body being affected, resulting in low platelet volume, which can generally be relieved by platelet transfusion. If low platelet volume is accompanied by a decrease in platelet count or abnormal changes in other routine blood data, a comprehensive analysis should be conducted and treatment should be provided for the specific disease under the guidance of a professional doctor.