The dose-limiting toxicity of carboplatin is primarily myelosuppressive, with thrombocytopenia being more severe than granulocytopenia. Carboplatin is not significantly nephrotoxic, but pretreatment renal function significantly affects the degree of carboplatin-induced thrombocytopenia. Animal studies have shown that renal clearance of carboplatin is accomplished exclusively by glomerular filtration without tubular involvement, and biliary excretion is less than 2%. Early studies noted that thrombocytopenia was more common in those with low pretreatment glomerular filtration rate (GFR), so investigators had recommended adjusting carboplatin dose according to GFR. 1984 Egorin et al. suggested that platelet nadir after intravenous administration of carboplatin correlated with free carboplatin AUC (area under the curve). Calvert et al. also concluded that the single-agent carboplatin dose of 400 mg/m2, established mainly on the basis of GFR at 60-100 ml/min, was not appropriate for those with high GFR. Therefore, a calculation of carboplatin dosing by AUC was proposed based on the linear relationship between the variable change in GFR affecting the AUC of free carboplatin and the dose administered. The carboplatin dose thus calculated achieves maximum efficacy and avoids intolerable toxicity. Calculation of carboplatin dosing by AUC: This is mainly based on the Calvert formula. The following conditions are first determined: gender, age, weight, serum creatinine and AUC, and the dose of carboplatin to be administered can be calculated by substituting the formula. 1. Calvert formula: Carboplatin dose (mg) = set AUC (mg/ml/min) × [creatinine clearance (ml/min) + 25] 2. This test is not often performed due to the complexity of creatinine clearance testing, but creatinine clearance can be calculated from serum creatinine (Serum Creatinine). Please note: Creatinine clearance is calculated differently in men and women. Male creatinine clearance (ml/min) = ｛[140-age (years)] × weight (Kg) × 1.23} ÷ serum creatinine (μmol/L) Female creatinine clearance (ml/min) = male creatinine clearance (ml/min) × 0.85 3. AUC (mg/ml/min) take value: often take 5 to 7, we often take 5.