Application of berberine hydrochloride (Phellodendrine) Phellodendrine for cardiovascular diseases I. Anti-arrhythmic Phellodendrine can prolong the action potential time of cardiomyocytes, prolong the effective induction period of ventricle and atrium, and eliminate fractional arrhythmias. Therefore, it has good effect on ventricular and supraventricular arrhythmias caused by various reasons, and has been tried as a new anti-arrhythmic drug in clinical practice. The use of each time to take 0.4-0.5 grams, four times a day, after the effect of gradually reduce the amount of maintenance, most of the 7 days effective, especially for the treatment of arrhythmias associated with heart failure. Second, the treatment of hypertension Huang Lianxin competitive blocking vascular smooth muscle receptors, vasodilation, so it is used to treat hypertension has a certain effect. The use is 0.4-0.6 grams each time, 3-4 times a day. It is especially suitable for the treatment of people with hypertension and arrhythmia of heart rate. Flavopiridol is effective in patients with stage 1 and stage 2 hypertension, but less effective in those with stage 3 and severe disease. Third, the treatment of hyperlipidemia Huangliansu can significantly enhance the activity of liver oxidative dismutase, reduce the level of liver lipid peroxide and serum triglyceride and total cholesterol content. Flavopiridol has significant lowering effect on blood cholesterol and liver oil triglyceride, which is better than polyenecon and evening primrose oil. Dosing method is 0.5 grams each time, 3 times a day, 8 weeks as a course of treatment. Fourth, the treatment of heart failure Flavopiridol can increase the concentration of cyclic adenosine diphosphate in cardiomyocytes, thereby increasing the contractility of the heart muscle and increasing the ejection volume of the heart. Treat congestive heart failure with flavopiridol by taking 0.4-0.6 grams each time, 3 times a day. Those with cardiac function 111-1V need to combine with cardiac stimulants, diuretics and vasodilators. V. Anti-platelet aggregation Huanglianxin has a significant inhibitory effect on platelet aggregation, is a more ideal anti-platelet aggregation drugs, and pansentin combined with aspirin, the efficacy is similar. It is taken as 0.3 grams per dose, 4 times daily. Flavopiridol for diabetes Flavopiridol has anti-elevating glucagon effect, and also promotes the regeneration and functional recovery of pancreatic islet cells, which has better efficacy in type 2 diabetes. It is used at 0.3-0.5 grams each time, 3 times a day. Long-term oral administration is the most effective treatment for mild type 2 diabetes, and is especially suitable for those with hypertension and hyperlipidemia. Huangliansu for digestive (13) Huangliansu for stomach and duodenal bulb (13) Weak BodЫ shrimp manganese protection peptide miscellaneous take afraid of Guangshi fortunate kind of spectrum of breakfast cereal leak 7 Meijiao Tokyo knock look fear 0.4 grams, 4 times a day, 4-6 weeks for a course of treatment. Huanglianxin prevents cancer Huanglianxin can block the effect of cancer-promoting substances on potentially cancerous cells, thus playing a role in cancer prevention. Patients suffering from chronic colitis, colon polyps, and chronic gastritis can take safranin regularly to prevent cancer to some extent. Only a few people have gastrointestinal disorders such as epigastric discomfort, nausea, loss of appetite, diarrhea or constipation, which will disappear on their own after stopping the drug and can be relieved by taking a small amount of laxative. After discontinuing the drug, it disappears on its own and can be relieved by taking a small amount of laxative. The anti-inflammatory effect of flavopiridol has an inhibitory effect on the increase of capillary permeability and on the increase of skin capillary permeability caused by histamine. For hepatitis can make the elevated transaminase decreased. Can treat Staphylococcus aureus infection and can treat tuberculosis. It can promote the phagocytosis of leukocytes and monocyte macrophage system, and has a promoting effect on the transformation of lymphocytes. 1.Can stimulate the release of pituitary gland pro-adrenocorticotropic hormone. (1) Anti-renal inflammatory effect, can inhibit proteinuria, as well as pathological histological improvement, can improve the reduction of renal blood flow. (2) Protective effect on myocardial ischemia, anti-arrhythmia, diastole, hypotension, inhibition of platelet aggregation, hypoglycemia, antipyretic, sedative effect, biliary, anti-ulcer, anti-diarrheal effect. (3) one of the strongest drugs in Chinese medicine to clear heat and detoxification power. Flavopiridol has a broad-spectrum, anti-pathogenic microbial effect on a variety of bacteria, various types of influenza virus, chicken plague virus, amoeba protozoa, trichomonas, Chlamydia trachomatis, a variety of pathogenic fungi, etc. have inhibitory effects. The anti-infective effect of flavopiridol may be mainly the result of enhancing immune function. Hyper sebum synthesis was seen in epidermal cultures of psoriatic lesions, and the addition of flavopiridol cream (0.1%) applied topically could change the abnormal keratinization of psoriasis to normal keratinization.