Clinically, we have received many patients with tumors, who initially had unexplained bone pain and thought that it was arthritis, osteophytes or rheumatism, and then they were treated with physiotherapy, massage or anti-rheumatism therapy. However, after the treatment, the pain not only did not reduce but also worsened, and it was not until coughing, fatigue or other symptoms appeared that they considered the possibility of tumors, and then they went to the oncology department for examination and found that they were suffering from tumors. There is a father Zhou who is more than seventy years old, usually insists on exercise and his health has been very good, but he likes to smoke a little bit of cigarettes. At one time, he felt a little soreness in his waist and back, and thought that it was osteoporosis, so he went to a clinic for physical therapy, and after a week, he felt that the soreness in his waist and back seemed to be alleviated a little bit, so he didn’t put the pain on his mind, and he exercised as usual. Who knows that after a few weeks, not only the lumbar pain aggravated again, but also the shoulder and leg pain in many places, and he went to the regular hospital and found that it was multiple bone metastases of lung cancer, and he had lost the chance of surgery. At this time, he regretted a lot: he claimed that he had never been in the hospital, and as a result, he got sick with terminal cancer. Tumor bone metastasis is very common in clinic, and the tumors that are more prone to bone metastasis are lung cancer, breast cancer, nasopharyngeal carcinoma and prostate cancer, etc. In fact, bone metastasis is very easy to be detected. In fact, bone metastasis is very good to be detected: the positive rate of bone isotope scanning (ECT) for tumor bone metastasis is as high as more than 90%, and it can be diagnosed about three months before the symptoms such as pain come out; magnetic resonance imaging (MRI) for vertebral bone metastasis is also very effective and does not cause any damage to the human body. Imaging such as CT and X-rays are also helpful in detecting bone metastases. Unlike visceral tumor metastasis, bone metastasis is usually not directly life-threatening in the short term, and the most common clinical manifestation is severe pain. The most common clinical manifestation is severe pain. Moreover, the pain is a persistent attack and will not be relieved significantly. If there are multiple metastases in the vertebral body, the bone damage is obvious, which may lead to vertebral compression fracture and cause paraplegia. Treatment of bone metastases is not difficult. The most effective conventional treatment is external radiation radiotherapy, which directly kills the cancer cells that have invaded the bone tissue. Radiotherapy has obvious pain-relieving effect and longer pain-relieving maintenance time, and it also has the effect of prolonging the survival period. Generally, DT30GY/2 weeks/10 times of radiotherapy is enough. After radiotherapy, 80%-90% of patients can expect to get longer lasting effect, and more than 70% of patients have remission period of more than 3 months. For systemic extensive bone metastases, it is best to use internal radiotherapy, i.e. isotope therapy, as long as the body allows even without hospitalization in the outpatient clinic can be treated, it is very convenient, and the efficacy is also very good. In addition, although bisphosphonates do not directly kill tumor cells, they can relieve pain and inhibit bone destruction, and are also used in clinical practice. Chemotherapy for pain relief is not as effective as the above three treatments, but it can prevent further spread of tumor and kill cancer cells, especially suitable for chemotherapy-sensitive tumors. Tumor bone metastasis has an obvious characteristic that it doesn’t like massage, the more it is pressed, the more it hurts, and the pain continues to flare up, and it won’t be significantly relieved if there is no treatment. Of course, not all bone pain should be considered to be the tumor. Only if we exclude other common diseases that cause bone pain, we should exclude the possibility of tumor bone metastasis.