It is the only high-tech medical system in the world that simultaneously combines ultra-low temperature freezing at minus 150 degrees, interventional thermotherapy, reversal of temperature difference at 200 degrees and immune enhancement. It is superior to hyperthermia or cryotherapy alone. It is more thorough and effective in killing cancer cells. This technology is purely physical therapy, which has the advantages of exact effect of complete destruction of tumor, no spread of cancer cells during treatment, minimally invasive and painless treatment process, fast recovery, and no damage to normal tissues; unlike radiotherapy, argon helium super-cooling knife treatment has no toxic side effects and can effectively regulate the secretion of cytokines and antibodies, and the immune function of patients after this method of treatment is significantly improved compared with that before treatment, and the long-term survival rate is significantly increased. In addition, it has the advantages of low treatment cost and short hospitalization time. It represents the advanced level of tumor treatment in the world. This technology is clinically applicable to the treatment of almost all solid benign and malignant tumors; malignant tumors such as liver cancer, lung cancer, prostate cancer, pancreatic cancer, breast cancer, brain tumors, abdominal and pelvic tumors, kidney and adrenal tumors, head, neck and skin tumors, metastatic gastrointestinal tumors, etc. Benign tumors such as: prostate hyperplasia, breast hyperplasia, hemangioma, uterine fibroids, cysts, warts, hemorrhoids, precancerous lesions, etc. It also has the effect of rapid pain relief and pain removal for cancer pain relief, etc. Ar-He supercooled knife is suitable for the treatment of early, middle and late stage solid tumors, especially for those patients in the middle and late stage who cannot be removed surgically, or those who do not want to operate due to various reasons such as old age and weakness; it is the first choice for patients who do not want to bear the side effects of radiotherapy and chemotherapy, or those who do not have good treatment effects such as radiotherapy and interventional therapy; meanwhile, using this technology can relieve patients’ pain and improve the comprehensive treatment effect. Most of the procedures are performed with local anesthesia, and the puncture is usually performed under the guidance of ultrasound, CT and MRI, and the whole process of puncture is monitored in real time. Surgical methods include percutaneous puncture, surgical puncture under direct vision, and lumpectomy puncture. The argon helium knife is accurately punctured into the tumor under CT or B-ultrasound guidance, and then the argon gas is first activated, which can be used to rapidly expand at the tip of the knife to produce cooling effect and freeze the lesion tissue to -120℃~170℃ within 15 seconds. After 15-20 minutes, the argon gas is turned off and the helium gas is started again, which can be used to rapidly expand at the tip of the knife and rapidly heat the lesion tissue in the ultra-low temperature state, causing the temperature of the lesion tissue to rise from -140℃ to -20℃~40℃, thus performing rapid thermal therapy. After 3~5 minutes, the above treatment will be repeated again. This kind of hot and cold reversal therapy is particularly thorough in destroying the diseased tissues. The speed, time and temperature of cooling and heating, and the size and shape of the destroyed area can be monitored in real time by ultrasound or CT, and precisely set and controlled by computer. More importantly, because argon helium knife cooling or heating is limited to the tip of the knife, the knife shaft does not cause hot or cold damage to the tissue in the puncture path. The Ar-He knife is the only instrument available for minimally invasive percutaneous cryotherapy. Ar-He knife cryotherapy can be used as an alternative treatment to surgery for small tumors in early stages. For advanced and larger tumors it can be used as palliative treatment to enhance the effect of comprehensive treatment, which can reduce tumor load, alleviate symptoms, improve quality of life and prolong survival time. Professor at Alconi General Hospital, an international oncology authority in the United States, confessed that ultra-low temperature therapy is so effective that within a few years it will start to become the first choice for the treatment of cancer. U.S. Dinesh Hospital Professor Kay said, “This therapy is not as invasive to the human body as other therapies, the patient’s hospital stay is short, and it kills the cancer cells exactly, making it an ideal choice for tumor patients.” Since 1999, when the Chinese State Administration of Medicine approved the entry of argon-helium supercooled knife into China, the famous Chinese academicians Wu Mengchao, Tang Zhaoyou, Hao Xishan, Professor Guo Zhi and other experts in China have applied this technology to treat more than 20,000 cases of mid- to late-stage liver cancer, lung cancer, breast cancer, pancreatic cancer, brain tumor, prostate cancer, kidney tumor, etc., and achieved remarkable results. In 2000, in view of the good efficacy and superior safety of Ar-He supercooled knife treatment, the United States included Ar-He supercooled knife treatment for solid tumors into the universal health insurance plan, and European medical insurance companies provide insurance for Ar-He supercooled knife treatment. More than 450 hospitals in the United States are now equipped with the U.S. Ar-He knife; more than 100 hospitals in China have also been equipped with the U.S. Ar-He knife, and Beijing, Tianjin and other cities have entered the medical insurance. Since July 2002, 35 state physician associations in the U.S. have designated the Ar-He knife as the preferred treatment for prostate cancer (the first in the U.S.), and the 2003 World Congress of Targeted Tumors recommended that the Ar-He knife be the first choice for mid- to late-stage lung and liver cancers.