Toxicity: Symptoms of poisoning are similar to those of arsenic poisoning: symptoms appear 2 to 5 hours after poisoning and include thirst and a burning sensation in the throat, fever, vomiting, diarrhea, abdominal pain, and kidney failure. This is followed by respiratory failure and death. Although various treatments exist, no antidote is available for clinical use at this stage. Adverse reactions: Colchicine is highly toxic, nausea, vomiting, diarrhea, abdominal pain, gastrointestinal reactions are the precursors of severe poisoning, and the drug should be stopped when symptoms appear. 1, gastrointestinal reactions: is the most common side effects. Many gout patients experience nausea, loss of appetite, vomiting, abdominal discomfort and diarrhea after taking colchicine. Some patients are unable to adhere to the medication because of nausea and vomiting or diarrhea is more serious. 2. Bone marrow toxicity: It mainly inhibits the hematopoietic function of bone marrow, leading to leukopenia, aplastic anemia, etc. 3, liver damage: can cause abnormal liver function, jaundice can occur in serious cases. 4, kidney damage: proteinuria can occur, usually does not cause renal failure. 5, other side effects: including hair loss, skin allergy, mental depression, etc. To reduce the side effects of colchicine, you can also use painkillers such as fenbid and diclofenac sodium in the acute stage. If there is liver and kidney damage, you can only use natural anti-inflammatory drugs such as natural astaxanthin (asta), dimethyl sulfone (DSM), or reduce uric acid with Yiyuan Benjamin tea, which can increase the rate of uric acid excretion by 30%.