Does celiac disease have an effect on conception?

  Women who go to the hospital for preconception or pregnancy checkups are often told after a gynecological examination that they have cervical erosion, which is not a separate disease but a manifestation of chronic cervicitis. Most chronic cervicitis is caused by untreated or incompletely treated acute cervicitis, with pathogens hiding in the cervical mucosa to form chronic inflammation. This condition is most often seen after childbirth, abortion or surgical injury to the cervix, where pathogens invade and cause infection. There are also some people who can have no history of acute cervicitis and present directly with chronic cervicitis. There is a specific type of cervical erosion, called pseudo-erosion, which occurs only in some physiological situations, such as in women during puberty and pregnancy, where the columnar epithelium of the cervical canal proliferates and migrates outward due to increased estrogen levels, resembling the pathological manifestations of cervical erosion. The incidence of celiac disease is 54.9% in women of childbearing age.  The common symptoms of cervical erosion 1, leucorrhea: leucorrhea is the main symptom of cervical erosion, sometimes even the only symptom. As the pathogenic bacteria cause different inflammation, and the nature, amount, color and smell of the leucorrhea is different. If the inflammatory infection is not obvious, the leucorrhea is mainly clear mucus; if the cervical erosion is accompanied by obvious inflammatory infection, the leucorrhea is yellow purulent and sticky. The amount of leucorrhea may be less if the area of erosion is small or the lesion is shallow; if the lesion is deeper and the area is larger with heavy erosion, the amount of leucorrhea is more; leucorrhea with bad odor is mostly anaerobic bacterial infection; with polyps, there may be leucorrhea mixed with blood, or bleeding during intercourse.  2, pain: cervical erosion appear pain symptoms is not rare, when the pathogen involved in the deeper range, can cause chronic parametrial connective tissueitis, lumbosacral pain, pelvic pain and dysmenorrhea. If the inflammation spreads to the main ligament, painful intercourse can occur, affecting sexual life.  3. Bladder symptoms: Inflammation of the cervix can spread to produce urinary symptoms around the bladder, resulting in frequent and painful urination symptoms, and sometimes secondary urinary tract infections.  Relationship between celiac disease and pregnancy The highest hormones during pregnancy cause the columnar epithelium of the cervical canal to proliferate and migrate outward, resembling the pathological manifestations of celiac disease, which improves after delivery.  Childbirth, especially vaginal delivery, causes different degrees of damage due to the dilatation of the cervix during labor and can have factors such as infection, suffering from acute cervicitis in the postpartum period, part of which turns into cervical erosion.  Mild and moderate cervical erosion does not usually cause infertility. Cervical erosion induces infertility only when the cervical erosion is severe and accompanied by other inflammatory diseases, the secretion of the cervix mixed with a large number of white blood cells and pathogenic bacteria, the secretion will be significantly more than before, and the texture is sticky, so that the normal micro-ecological environment of the vagina, the physiological environment is damaged, sperm motility is restricted, survival time is shortened; cervical mucosa due to inflammatory stimulation of hyperplasia, there can be polyps blocking the cervical opening, directly The cervical mucus is sticky, which hinders the normal movement of sperm and also prevents sperm from entering the uterine cavity, which reduces the chance of sperm and egg union, thus causing female infertility.  In severe cervical erosion with infection, the inflammation can spread through the lymphatic system, and directly up and to the paracervical inflammation, which can cause chronic paracervical connective tissue inflammation and pelvic inflammatory disease, which can cause blockage of the fallopian tubes so that the sperm and egg cannot have a chance to fertilize, or there may be stimulation of inflammatory substances that can affect fertilization and cause infertility.  Celiac disease is suitable for preconception women Talking about celiac disease should not be equated with cervical cancer. Most celiac disease for is an inflammatory and physiological condition that needs to be clinically differentiated from cervical intraepithelial neoplasia (a collective term for a group of pre-cancerous lesions closely related to invasive cervical cancer) and early cervical cancer. Regular cervical cytology and screening for HPV infection, which has been associated with cervical cancer, can be performed, and women who are preparing to become pregnant can be screened for this before and early in pregnancy to rule out abnormalities.  There are two main types of treatment for cervical erosion, physical therapy and medication.  It is not recommended to over-treat all cases of cervical erosion. If the erosion is due to migration of the columnar epithelium and is not accompanied by other inflammatory conditions, treatment is not necessary. Regular gynecological examinations are possible.  Physical therapy includes, electrocautery, freezing, laser, microwave and Leep knife. It mainly destroys or removes the cervical erosion surface and allows new cells to cover the surface. The treatment is more effective and has a lower recurrence rate, but it is destructive to the cervix, especially in severe cervical erosion, where the treatment is deeper and there is scar tissue at the cervical opening, which sometimes has an effect on the dilatation of the uterus during delivery. Treatment before conception is generally not advocated.  There are also some medications available for anti-infective treatment of concomitant other inflammatory conditions.  For those who are ready to conceive and have a high discharge with infection, medication can be used to reduce the discharge and improve the vaginal microecological environment, which is conducive to conception.  For severe cervical erosion, if other causes of infertility are excluded and it is indeed the cause of infertility, and if conception is still not possible after drug treatment, physical therapy can be used, and in some patients, conception occurs after treatment.  Causes of recurrence and prevention Physiotherapy for celiac disease rarely recurs. The possible reasons for recurrence are: 1. Incomplete treatment: especially for severe celiac disease, the treatment is small, and after treatment the symptoms are found to disappear or improve, and the review reveals that there is still celiac disease.  2, frequent sex life: during the treatment of cervical erosion, because the trauma is not yet fully repaired, it is not appropriate to have sex life, but some patients comply with medical advice, so that the efficacy of the treatment is reduced or even invalid; after treatment, sex life is too frequent, is also a good recurrence of cervical erosion crowd. Multiple sexual partners, excessive intensity of sexual life (more than 4 times a week), and sexual life during menstruation are also causes of cervical erosion that cannot be ignored.  3, poor body resistance: generally young women have better physique than middle-aged or elderly people, so they recover quickly after treatment, while some middle-aged and elderly people have poor physique or have their own diseases such as diabetes, which prolong the healing time of the trauma. And it is easy to recur.  4.Patients with vaginitis at the same time: celiac disease and vaginitis are very closely related. Long-term inflammation of the vagina leads to cervicitis and celiac disease, while patients with celiac disease, vaginitis is not cured, it is easy to recur.  5, after treatment childbirth and multiple abortions: re-birth cervical damage, repeated abortions can also cause varying degrees of cervical damage, giving germs the opportunity to take advantage and trigger cervicitis. Due to the stimulation of inflammation, local secretions increase, the cervix is impregnated with inflammatory secretions for a long time will cause erosion.  6, the treatment is not standard: mild cervical erosion is possible with medication, but may not be standardized with medication, and wrong medication.  To prevent recurrence of cervical erosion, treatment needs to be standardized and achieve therapeutic effect, increase resistance after treatment, promote healing of treatment wounds, as well as treat the accompanying vaginal infections and avoid factors that may recur.