Clindamycin gel rubbing acne usually works within 3-5 days. Clindamycin gel is an antibiotic-based topical ointment that can be applied to the face to inhibit Propionibacterium acnes inside acne to a certain extent, thus achieving the purpose of treating acne. Patients apply it twice a day to the surface of the skin, which allows the effect of the medicine to reach the lesion directly through the skin, and it usually takes 3-5 days to take effect. If the time is too short, the effect of the medicine does not reach the lesion will not play a significant role. Therefore, this drug needs to be applied for a long time to achieve the desired treatment purpose. In addition, it is recommended that patients apply clindamycin gel along with oral tetracycline type of medication for a comprehensive treatment to make the acne removal more effective. The actual fact is that, before the acne is completely gone, it is advisable to eat less chili and less sweets to avoid aggravating the acne and affecting the effect of the medication.