With the improvement of living standards, people’s health awareness is getting stronger and stronger, and many people have to do health checkups every year. However, a large proportion of them forget about gastrointestinal tract in their annual health checkups or give up because they are afraid of having gastrointestinal tract checkups. Cancer is a common and frequent disease that seriously endangers people’s life and health, and the number of cancer cases in China is about 1.6 million every year. Cancer is overtaking cardiovascular disease as the first cause of death. The esophagus, stomach and large intestine in the digestive tract are the most common sites of cancer, and cancer patients in these three areas account for more than a quarter of common malignant tumor patients. Among the top five deaths due to cancer, stomach, esophagus and colon cancer occupy the first, third and fifth places; in the world, China has the highest incidence and mortality rate of esophageal cancer, and half of the patients with esophageal cancer are Chinese. In Asia, the incidence rate of gastric cancer in China is among the top three, and due to the large population in China, 160,000 people die from gastric cancer every year. Colorectal cancer, including colon cancer and rectal cancer, ranks second in Europe and the United States in terms of incidence rate, while China ranks fifth among various cancers, and the incidence rate has increased significantly in recent years. How can we change the high incidence rate of digestive tract cancer, many deaths and great harm to people’s health? First of all, we should take measures against cancer-causing factors, among many cancers, digestive tract cancer is most closely related to environmental factors, and there is some truth in the saying that “cancer enters by mouth”. “Early detection, early diagnosis, and early treatment are all important. To achieve this goal, medical personnel and the general public need to act together, change customs, change unreasonable dietary habits, protect the environment, raise awareness, recognize and detect cancer at an early stage. The higher mortality rate of digestive tract tumors is related to the late stage of patients when they obtain the diagnosis. In developed countries such as Europe, America and Japan, the proportion of early diagnosis of GI tumors can reach 30%~50%, while China has been hovering at 10%~15%. In recent years, the development of gastrointestinal endoscopy technology has provided us with an effective weapon to diagnose and treat early cancers of the GI tract. In China, gastric cancer is the first cause of death from malignant tumors, accounting for 23.03% of deaths from malignant tumors, and about 160,000 people die from gastric cancer every year. In addition, the incidence of colorectal cancer is also increasing year by year. How to “kill” the tumor at the early stage is a question that every doctor is thinking about, and the application of new technology of gastrointestinal endoscopy, such as staining technology and magnifying endoscopy, has given gastroenterologists more wings. Early stage gastric cancer is defined as gastric cancer limited to mucosa or submucosa, regardless of the size of the lesion or the presence of lymph node metastasis. With timely treatment, the 5-year survival rate of early gastric cancer can reach 90%. In contrast, most of the gastrointestinal cancers in China are found in the middle and late stages, because the symptoms appear only in the middle and late stages, and the 5-year survival rate is only 16.6%. Early gastric cancer can be treated minimally invasively under endoscopy, i.e., mucosal resection (EMR) or submucosal dissection (ESD). In contrast, patients with intermediate and advanced stages often have to undergo radical surgical procedures, or even have lost the chance of radical resection. I suggest that the following high-risk groups should be added to the gastroscopy program when performing routine physical examinations: middle-aged people over 40 years old with a family history of tumors; chronic gastritis, moderate atypical hyperplasia, gastric bleeding, intestinal bleeding in the previous gastroscopy; polyps in the stomach, and mucus stools and bloody stools in the stool.