The patient, a 54-year-old male, was admitted to the hospital with “a heart murmur found on physical examination for more than 40 years and chest tightness after activity for more than 2 years”. He was diagnosed with “congenital heart disease, right-sided heart, ventricular septal defect, and pulmonary hypertension” based on his medical history, symptoms, signs, and ancillary examinations (ECG, chest X-ray, and echocardiogram). After thorough preparation, interventional closure of the ventricular septal defect was performed under local anesthesia. The operation was successful and he was discharged with a 5-day hospital stay. He was hospitalized for 5 days. He was reviewed several times after the operation and had good results. He is now able to perform normal physical work. The main procedures of the operation are shown in Figure 1, Figure 2, Figure 3 and Figure 4. Difficulties of the operation: 1. The patient had a right-sided heart with abnormal anatomy, which was different from the conventional operation and required the operator’s understanding of the three-dimensional anatomy of the heart; 2. The ventricular defect diameter of the patient was large, 14 mm; 3. The ventricular defect blocker (18 mm) was applied, and the blocker was successfully blocked once. Figure 1: The patient has a right-sided heart, with the heart in the right thoracic cavity, the ascending aorta on the left and the descending aorta on the right Figure 2: The left ventriculogram shows a huge septal defect Figure 3: The left ventriculogram again after blocking, and it shows that the shape of the blocker is satisfactory and there is no residual shunt Figure 4: The aortic root angiogram, and it shows that the blocker has no effect on the aortic valve