The etiology of abdominal cocooning is unknown and may be related to the following factors 1, secondary to some kind of intra-abdominal inflammatory disease: Foo et al. believe that the disease mostly occurs in women, the onset of which is often within 2 years of menarche, presumably due to the reflux of menstrual blood through the fallopian tubes into the abdominal cavity, which induces subclinical primary peritonitis fibrous exudative mechanization. sieck et al. based on the regional nature of the onset and the prevalence in adolescent females, presumably due to retrograde infection by pathogens that can easily invade through the genital tract The sequelae of peritonitis. However, these speculations have not been confirmed and do not explain the onset in male patients, and the intraperitoneal inter-intestinal adhesions found during surgery are also different from the general infection-induced peritoneal adhesions. 2, congenital developmental abnormalities: most scholars believe that abdominal cocooning is due to congenital developmental abnormalities combined with acquired causation, on the grounds that the peritoneum is intact, smooth, and not adherent to the wall peritoneum, and some peritoneal pathological examinations confirm peritoneal structures, with a high rate of intra-abdominal concomitant malformations (54.3%), often with large omental defects. It is speculated that this may be due to abnormal development of the greater omentum or a double-sleeve development of the small intestinal mesentery, and the cause of intraperitoneal adhesions may be related to acquired factors. It is also believed that abdominal cocooning is a congenital paraduodenal hernia or colonic mesenteric hernia. 3, drug effects: Seng reported cases with a history of taking propranolol (insulin) (80mg/d), it is believed that propranolol-like β-blockers reduce the ratio of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) that control normal cell proliferation, leading to excessive collagen proliferation and abdominal fibrosis. 4, primary peritonitis: Francis noted a high incidence of abdominal cocooning in patients with cirrhosis, nephritis, malignancy and heart failure with ascites, especially in patients with cirrhosis after LeVeen shunts.