Diabetic peripheral neuropathy can be relieved by symptomatic treatment such as nerve nutrition, causative treatment such as lowering blood glucose, and adjuvant treatment such as acupuncture and physical therapy, but it cannot be cured yet. 1. Symptomatic treatment: drugs such as pancreatic kininogenase, lipoic acid, epoprostenol, methylcobalamin, etc. can improve microcirculation and nourish the nerves, which can alleviate the symptoms of sensory abnormality; for the patients who have obvious pain, drugs such as duloxetine and gabapentin can be applied to alleviate the pain. 2. Treatment of the cause: long-term high blood glucose level leads to oxidative stress, causing peripheral neuropathy, so hypoglycemic treatment can inhibit the progress of the disease. Metformin, glimepiride, saxagliptin and other hypoglycemic drugs or insulin preparations such as Degu insulin can be used to lower glucose. 3. Adjunctive treatment: Acupuncture and other modalities have a certain alleviating effect on diabetic peripheral neuropathy. Pay attention to the use of medication under the guidance of a physician. When discomfort occurs, consult a doctor promptly.