Cirrhosis is often the final destination of various chronic liver diseases, and the most important direct cause of death in cirrhosis is portal hypertension complicated by upper gastrointestinal hemorrhage. There are two theories of the cause of upper gastrointestinal hemorrhage in portal hypertension in cirrhosis, one is the “explosion theory”, which refers to the increased pressure of portal vein, varices of gastric fundus and lower esophagus, excessive internal pressure, and finally vascular burst causing hemorrhage, this theory is currently accepted by most people; one is the “corrosion theory This theory is currently accepted by most people; one is the “corrosion theory”, which refers to the increased secretion of gastric acid, accompanied by H. pylori infection in the stomach, gastric mucosa erosion, the varices of the fundic esophageal vein due to increased portal pressure and constant “corrosion”, resulting in rupture of blood vessels and bleeding, this theory is confirmed by supporters, more than 80% of people with portal hypertension combined with H. pylori infection. We believe that both factors are present and should be prevented. Upper gastrointestinal hemorrhage comes with a vengeance, and sometimes patients develop it at home, on foot, on travel, in conversation, etc., and tragedy occurs before they have time to go to the hospital. Therefore, patients with cirrhosis combined with portal hypertension must be more aware of prevention and take appropriate measures. Under the guidance of doctors to apply insulin to reduce portal hypertension some people have observed that patients with portal hypertension taking this drug for 3 months can reduce the portal pressure by more than 20%, and only 2 out of 25 patients with portal hypertension had bleeding during the 2-year follow-up. The heart rate should be observed during application. The heart rate should not be less than 60 beats/min. The general dose is 20 mg per dose, taken 3 times a day, or the dose may be increased to 40-50 mg per dose, preferably at an individualized dose, but generally not more than 160 mg/day. Calcium antagonist nifedipine 10 mg each time, 3 times a day orally, there are people apply isosorbide nitrate, 20 mg each time, 3 times a day, to prevent bleeding effect of more than 90%. Other calcium antagonists such as verapamil, Hanfangan methyl, etc., all have a certain effect of lowering portal pressure. Acid-suppressing and anti-inflammatory drugs selected from Loxacel combined with amoxicillin have better effect in inhibiting gastric acid and clearing H. pylori. Doctors in Shanghai report that the use of the above drugs to prevent bleeding in hospitalized patients is up to 100% effective. For patients with portal hypertension, we use “Danshen incremental method” intravenous drip treatment after hospitalization and receive good results. The specific usage is: 30 ml of Salvia injection is added to 10% glucose solution intravenously, and 10 ml of Salvia is increased every 3-5 days, up to 70-80 ml/time, most of them are 50-60 ml/time. After 1 to 3 months of application, no bleeding occurred in any case. At the same time, different degrees of spleen shrinkage were observed, and no obvious toxic side effects were found. However, hemorrhage is caused by blood vessel rupture, and the blood activation of salvia is to dilate blood vessels, increase the lumen of blood vessels, reduce the resistance to blood flow, and thus lower the pressure of blood vessels, which will not cause hemorrhage. Moderate or mild platelet hypotension is not a contraindication. Prevention of upper gastrointestinal hemorrhage in portal hypertension must take comprehensive measures, do not expect one drug and one method to work miracles, can choose 2 or even 3 methods of combined application. At the same time, patients should pay attention to daily life, diet and other aspects, but also to maintain an optimistic psychological state. Although portal hypertension is an advanced complication of liver disease, it is possible to prolong life and improve quality of life if medication is used as prescribed by the doctor.