Diabetic toe ulceration is usually related to long-term poor control of blood sugar, poor blood circulation, lack of nerve nutrition, infection and other factors, according to the cause of the lowering of glucose, improve blood circulation, nerve nutrition, anti-infection and other treatments, can be used externally to disinfect the wound and keep hygiene and cleanliness. 1. Glucose lowering: diabetic patients with persistent poor control of blood sugar, causing diabetic foot, easy to cause toe ulceration. Glucose-lowering drugs should be used regularly to maintain blood sugar within the target range. 2. Improve blood circulation: diabetic patients with long-term sedentary, standing, small amount of exercise, coupled with high blood sugar, can lead to lower limb blood circulation is relatively poor, easy to lead to toe ulcers. It is recommended to increase the amount of activity appropriately, accelerate blood circulation through massage, etc., and apply medicines to protect blood vessels. 3. Nutritional nerves: high blood sugar in diabetic patients can easily lead to the occurrence of neuropathy, resulting in toe ulcers. Oral nutritional nerve drugs, such as vitamin B12, should be taken as prescribed by the doctor. 4. Anti-infection: diabetic patients with poor immunity, prone to bacterial and fungal infections, can be taken against the pathogen drug therapy. Diabetic patients with toe ulcers, should be under the guidance of a professional physician to use medication, to avoid unauthorized use caused by adverse reactions.