Insomnia, night terrors, nightmares and excessive sleep are common clinical complaints and also common symptomatic manifestations of depression; 1. Depressed patients have sleep structure disorders; 2. Escitalopram can modulate the sleep structure and improve sleep symptoms in depressed patients; 3. Intervention strategies for sleep disorders in depressed patients. Sleep symptoms such as night terrors, nightmares, insomnia, and excessive sleep are complaints we often encounter in our clinical work, and they are also the most common manifestations of sleep disorders in depressed patients. For this group of patients, the simple administration of sedative sleep aids does not completely relieve their distress. Polysomnography shows that depressed patients have shorter REM sleep latency, more stage REM sleep activity and less deep slow wave sleep compared to the general population, thus predisposing them to clinical manifestations such as insomnia, discontinuous sleep and early awakening. Escitalopram has a regulatory effect on the sleep rhythm of depressed patients, on the one hand, it can convert REM sleep to slow-wave sleep, on the other hand, it can weaken the activity of melanin aggregating hormone neurons, thus reducing REM sleep. SSRIs combined with benzodiazepines can be considered for patients who urgently need to address insomnia symptoms; pro-wakefulness SSRIs represented by escitalopram can be used for patients with drowsiness and fatigue; for patients with persistent sleep disorders, sleep education and light therapy are needed in addition to pharmacotherapy.