The gastric sinus is a part of the stomach that is distal to the stomach near the duodenum. Gastric sinus malignancy refers to gastric cancer that grows in the area of the gastric sinus, which is also a favored site for gastric cancer. Helicobacter pylori is thought to be a common cause of gastric sinus cancer, while chronic atrophic gastritis, intestinal metaplasia of the gastric mucosa and gastric ulcers are also thought to be closely related to gastric sinus malignant tumors, as well as cigarette smoking and alcohol abuse, and familial heredity are also contributing factors. Surgery is the main treatment for gastric sinus malignant tumors, early gastric sinus malignant tumors have a good prognosis, and the five-year survival rate of early treatment may reach ninety percent, while the middle and late gastric sinus malignant tumors need chemotherapy (e.g., 5-fluorouracil, vincristine, contendamycin and so on) and other comprehensive treatments, and the five-year survival rate is lower. Gastroscopy and pathology are the gold standard for detecting and confirming the diagnosis of gastric sinus malignancy. Gastric sinus malignant tumors should strive for early treatment.