The cause of cholinergic urticaria is not clear, and it usually has no significant correlation with the kidneys, and is more often than not significantly associated with heat exposure and stress. Cholinergic urticaria belongs to a kind of urticaria, which can appear after exercise, mood swings, mental stress, drinking hot food or taking a hot bath. When the body is stimulated to cause the release of acetylcholine from cholinergic nerves, the level of cyclic guanosine monophosphate increases in basophils and mast cells, leading to the release of histamine and the onset of the disease, which may appear as tiny windswept bumps with marked itching. There is no evidence that the disease is usually associated with the kidneys, and in most people the symptoms subside spontaneously within a short period of time, usually without affecting the lifespan of the organism. The chances of occurrence can be reduced after avoiding triggering factors such as exercise, heat and stress.