Can colorectal cancer with distant metastasis still be operated? Colorectal cancer as a common tumor poses a great threat to human beings. About one-third of colorectal cancer patients have metastasis at the time of diagnosis, among which liver metastasis takes the first place, followed by lung metastasis, retroperitoneal metastasis and so on. Currently, it is believed that distant metastasis of colorectal cancer can also have surgical value, and simultaneous or staged resection of primary foci and metastatic foci can get better therapeutic effect. Foreign countries reported that the five-year survival rate of simultaneous or heterochronous liver metastasis can reach 35-40% after active treatment. Can distant metastasis of gastric cancer still be operated? The pathological process and treatment of gastric cancer are quite different from that of colorectal cancer. Generally, the treatment effect is not satisfactory and the five-year survival rate is low after the occurrence of distant metastasis. Generally, distant metastases are secondary tumors in distant sites or organs, such as liver, lung, pelvis, female ovary, bone and brain. Distant metastases cannot be localized by direct invasion of the tumor into surrounding tissues, such as the transverse colon, spleen, liver, pancreas, diaphragm, and adrenal glands. Surgery is not recommended for patients with distant metastases. If complications such as hemorrhage, perforation, or obstruction occur, surgery can be performed to resolve life-threatening emergencies, and radical resection is not the primary goal. Should I give up aggressive treatment for advanced tumors? Advanced tumors are defined as tumors with distant metastases or severe tumor invasion that cannot be completely removed by surgery. The current domestic and international consensus is that advanced tumors are divided into locally advanced and distant site metastasis. The former can be downstaged by neoadjuvant radiotherapy to achieve R0 resection and thus produce curative effect. The latter can also be actively treated to create opportunities for further treatment. So don’t give up when you encounter advanced tumors, a little bit more positive will give you more hope.