Photodynamic treatment (PDT) Photodynamic treatment (PDT) involves injecting a specific photosensitizer (light-activated drug: Vesodar) into a blood vessel, which follows the blood flow to the abnormal neovascularization. A special non-thermal laser (cold laser) is then used to destroy the abnormal neovascularization without damaging the normal retinal neuroepithelial tissue. Photodynamic therapy works selectively with the neovascularization to maximize normal tissue and protect vision. Photodynamic therapy can stop the progression of the lesion, maintain the patient’s visual acuity, contrast sensitivity and other visual functions, reduce the central dark spot, improve the patient’s reading speed, and can maintain the quality of vision for a long period of time, so that the quality of life can be maintained. Those patients with small fresh lesions can also improve their visual acuity if they are seen in time for early detection and treatment. In addition, the treatment of macular neovascularization can be combined with some anti-angiogenic drugs, injected into the vitreous cavity, such as hormones (Trimethoprim TA), anti-neovascular growth factor (Luncentis, Avastin), etc., and can be combined if necessary, multi-pronged, complementary, so as to achieve the best results. However, no matter which approach is used, it is a symptomatic rather than curative treatment, and it cannot relieve the cause of macular neovascularization, and there is a possibility that multiple treatments will be needed. Indications, steps and precautions for photodynamic therapy (1) The main indications for photodynamic therapy are as follows: 1. Choroidal neovascularization in and around the macula caused by various reasons (age-related macular degeneration, mesophthalmos, high myopia, etc., angioid streaks on the fundus, choroidal neovascularization caused by choroidal osteochondroma, etc.). 2. 2.Some intraocular tumors, such as choroidal hemangioma, choroidal melanoma, optic papillary hemangioma). 3, Polypoid choroidal vasculopathy (PCV): often massive hemorrhage in the deep layers of the fundus, similar to age-related macular degeneration. 4.Retinal hemangioma, retinal hemangioma-like hyperplasia. 5, Central plasma choroidal retinopathy (“central plasma”). 6, Optic papillary neovascularization, abnormal retinal blood vessels in Coat’s disease (conventional laser does not work due to massive exudation) (ii) Steps in photodynamic therapy (iii) Side effects Adverse reactions can occur with any medication, and are commonly a type of temporary blurring of vision or other visual disturbances, transient back pain during infusion, and localized reactions to the injection. The first two are usually transient and can be quickly recovered, and the latter can be avoided through regular infusion procedures. (D) Precautions: 1. Before treatment: follow the doctor’s instructions for fundus angiography and other tests to clarify the diagnosis; on the day of treatment, you need to prepare sunglasses, gloves, long-sleeved pants and long-sleeved clothes, bandanas or hats; 2. After treatment: 48 hours to avoid bright light exposure. Lights to be avoided are strong daylight, dental and surgical light sources, and bright halogen lamps. Keep bowel movements clear. Usually rest at home away from light for 5-7 days. 3, after surgery, according to the physician’s instructions for regular review, which is very critical, generally each review requires OCT examination, 3 months to carry out a fundus angiography.