HP infection, that is, Helicobacter pylori infection, is widely treated clinically using quadruple therapy, that is, proton pump inhibitors plus bismuth, two antibiotics in combination, has a better therapeutic effect. Specific drugs are as follows: 1, proton pump inhibitors: the main role of inhibiting gastric acid secretion, including omeprazole, lansoprazole, pantoprazole, rabeprazole and estrametrazole and other drugs; 2, bismuth: a gastric mucosal protective agent, usually choose bismuth potassium citrate or bismuth pectin; 3, two antibiotics: commonly used drugs are amoxicillin, clarithromycin, levofloxacin, minocycline, etc., have a strong antibacterial effect, can control the infection. It should be noted that the drugs should be used under the guidance of the doctor, not to blindly increase or decrease the dose or mixed with other drugs, so as not to cause adverse reactions. A regular course of treatment is 10-14 days, do not stop the drug in the middle of the treatment, so as not to affect the therapeutic effect, stop the drug for about a month and then recheck the carbon 13 or carbon 14 breath test, to clarify whether H. pylori has been completely cleared. In addition, attention should be paid to abstaining from alcohol during medication, and not to prepare for pregnancy during medication. The appearance of rash during medication should be communicated to the doctor in time to avoid adverse consequences.