Patients with rheumatoid arthritis and ankylosing spondylitis are sometimes recommended to use biologics. Here is a brief introduction to commonly used biologics and their precautions. 1.What is the nature of biologics? Tumor necrosis factor has been shown to play an important role in rheumatoid arthritis and ankylosing spondylitis, so the efficacy of drugs targeting tumor necrosis factor is significantly stronger than the combination of traditional drugs. According to common parlance, biological agents can be called “special drugs” for the treatment of rheumatoid and ankylosis, but they are not effective for 100% of patients, and some patients may not get relief from joint pain soon after using them. 2.What kinds of biological agents are there? There are differences in the mechanism of action, method of use and price of biologics, which should be used under the guidance of physicians. 3.What patients need to use biological agents? There are two types of patients need to use biological agents, one is the use of traditional drugs in combination with the effect is not obvious; the second is the basis for the discovery of early joint destruction, such as rheumatoid patients ultrasound or magnetic resonance imaging found to have bone erosion, or ankylosing spondylitis patients already have hip joint involvement (may lead to disability). 4.What preparation is needed before using biological agents? Active infection, active hepatitis and comorbidities such as tumor must be excluded before using biologics. Routine blood, liver function, complete set of hepatitis B and tuberculosis PPD skin test need to be completed, and the results are normal before starting to use, and regular review is required. 5.Why do we need to prepare ice bags for transporting biological agents? Because biological agents are biologically active drugs, they can be stored at 4℃ to ensure that their efficacy is not affected. Therefore, before going to the pharmacy to pick up the medicine, you should prepare an insulation bag, the pharmacy will give an ice bag, which can provide 6~8 hours protection effect after putting into the insulation bag. When you get home, you should immediately put the medicine in the freezer of the refrigerator, and make sure not to put it in the freezer. To the clinic for injections also need to bring ice bags, so as not to affect the effectiveness of the drug. 6.Does the biological agent have any effect on children? Many parents worry that biological agents may affect growth and development, or become addicted to them. For one thing, arthritis itself is the main reason to affect growth and development. Secondly, the dosage of biologics can be gradually reduced and stopped after the joint pain is relieved, and it usually lasts for a long time after the drug is stopped. 7.When do I need to stop using biologics? The common side effect of biologics is to cause injection site reaction, which usually does not require special treatment. However, some patients may develop infection, so patients with fever, cough and sputum and other manifestations of infection should suspend their use and continue to use them after the infection is well controlled. Patients who use biological agents need to stop using them for more than 30 days before they can get pregnant; patients with unplanned pregnancy must also stop using them once it is clear. 8.Does the biological agent need to be hospitalized before use? Usually not. The use of such drugs as Ixepro can be brought back to fight, but the class of grams because some individual patients may have obvious reactions, therefore require the use of the hospital, by a special nurse to monitor the use of the process, also does not require hospitalization.