High immunoglobulin E, which is an increase in total IgE, is accompanied by urticaria, which requires symptomatic treatment with anti-allergy medication and active removal of the causative factors. An elevated total IgE is an important diagnostic tool for allergic diseases and a common test in the treatment of urticaria. Urticaria is due to allergens into the body, resulting in increased permeability of subcutaneous capillaries, and the formation of a temporary, elevated, limited erythema as the main feature of vascular allergic reaction disease, in the treatment, mainly including drug therapy and removal of allergens. 1. Drug therapy: timely administration of some long-acting antihistamines can quickly improve the symptoms of urticaria, such as oral levocetirizine capsules, ebastine tablets and so on. The drugs should be used according to the doctor’s instructions. 2. Remove allergens: perfect allergen testing can be clear allergens, timely removal of allergens is the key to the treatment and prevention of urticaria. As the severity of the symptoms of urticaria varies from person to person, there will be some changes in the treatment, the specific circumstances need to ask the doctor for an interview, the drug should be used as prescribed by the doctor.