Waking up during sleep with symptoms such as heartburn is common in two cases. In the first case, the patient wakes up due to nightmares. In this case, sympathetic excitation is induced by mental stimulation, which manifests as panic attacks, chest tightness, profuse sweating and other accompanying symptoms, which are physiological changes. Deliberate medication is generally not required, but patients need to pay attention to adjusting their emotions and avoid watching images with horror-stimulating components before going to bed. If the symptom relief is not satisfactory, sedative drugs can be taken to relieve the symptoms. The second condition is a sudden onset of heart disease during sleep. In addition to panic and fear, patients often have a combination of significant dizziness, chest pain, chest tightness, and other pathological changes. Meanwhile, the relief by rest is not satisfactory, and it is generally recommended that an emergency electrocardiogram as well as cardiac enzyme tests be performed to assist in the diagnosis.